【摘 要】
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BACKGROUND AND OBJECTIVEA recent meta-analysis demonstrated that atrial fibrillation (a-fib) is associated with a four- to five-fold increase in the risk of stroke, and a 40% increase in the risk of c
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BACKGROUND AND OBJECTIVEA recent meta-analysis demonstrated that atrial fibrillation (a-fib) is associated with a four- to five-fold increase in the risk of stroke, and a 40% increase in the risk of cognitive impairment. This meta-analysis was designed to better understand the association between a-fib and silent cerebral infarctions (SCIs).
METHODSFive databases were searched for observational studies involving adults with a-fib, and no clinical history of stroke or prosthetic valves. Studies eligible for inclusion reported prevalence or incidence of SCIs among patients with a-fib or for which the risk estimate could be calculated.
RESULTSEleven studies including 5, 317 adults were included in the final analysis. The mean ages in the studies ranged from 50 to 83.6 years. The overall prevalence of SCI among patients with a-fib was 40% by MRI and 22% by CT. A reduction in the incidence of SCI was not found through the use of anticoagulants.
CONCLUSIONThis meta-analysis of studies involving patients with no history of stroke found that silent cerebral infarctions can be detected on MRI in 40% of patients with a-fib, and that a-fib carries a twofold increase in the risk of SCI.
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