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目的 分析临床急性感染性疾病所致肝功能损害的特点及其恢复时间。方法 对 135例急性感染性疾病患者入院肝功能指标进行分析 ,观察治疗第 2周及第 4周时患者异常肝功能指标恢复情况。结果 除 6例死亡外 ,其余患者异常肝功能指标升高多在正常值上限 3倍以内 ,治疗第 4周异常肝功能指标治愈率分别为 AL T92 .4%、AST91.6 %、GGT75 .6 %、AL P91.3%、 SB10 0 %、 SB’ 10 0 %和 TBA 85 .7% ,HBs Ag (+ )携带者与 HBs Ag (- )者治疗第 4周上述指标治愈率无显著差异。第 4周时 GGT仍升高者恢复缓慢或不易恢复正常。结论 急性感染性疾病致肝功能损害多呈轻度及一过性升高 ;HBs Ag (+ )携带者肝脏应急储备及修复功能较正常人无明显下降 ;GGT恢复缓慢或不易恢复正常者可能留有持久性的肝内毛细胆管损伤
Objective To analyze the characteristics of liver dysfunction caused by acute infectious diseases and its recovery time. Methods 135 patients with acute infectious disease in patients with liver function indicators were analyzed to observe the second and fourth week of treatment of patients with abnormal liver function recovery. Results In addition to the 6 deaths, the abnormal liver function indexes of other patients increased more than 3 times of the upper limit of normal value. The cure rates of abnormal liver function indexes of the 4th week of treatment were AL T92.4%, AST91.6%, GGT75.6 %, P91.3% of AL, 0% of SB10, 100% of SB and 100% of TBA. There was no significant difference in the cure rate of the above indexes between HBs Ag (+) carriers and HBs Ag (-) recipients in the 4th week. Week 4 when the GGT is still recovering slowly or not easy to return to normal. Conclusions The liver damage caused by acute infectious disease mostly showed slight and transient increase. There was no significant decrease in liver emergency reserve and recovery function in HBs Ag (+) carriers. The GGT recovery was slow or not easy to recover There are persistent intrahepatic bile duct injury