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抗精子抗体(ASA)是不育的一个相关因素,ASA的存在似乎降低了妊娠。有作者指出,精液体外处理技术的应用,可以降低精浆中ASA浓度及精子表面免疫球蛋白的吸附。然而在大多数病例,ASA与相关抗原(Ag)的亲和力很强,并且射精后ASA-Ag的结合是立即发生的。从理论上讲,不论是阻止ASA-Ag复合物的形成,还是在复合物粘附于精子后进行单纯洗涤、高速离心或尝试通过改变pH值等方法以分离ASA-Ag复合物,只能导致不可逆的精子损伤和活力减低。因此当
Antisperm antibody (ASA) is a related factor in infertility, and the presence of ASA appears to reduce pregnancy. Some authors point out that the application of sperm extracorporeal treatment technology can reduce the seminal plasma ASA concentration and sperm surface immunoglobulin adsorption. In most cases, however, the affinity of ASA for the relevant antigen (Ag) is very high and ASA-Ag binding occurs immediately after ejaculation. Theoretically, either blocking ASA-Ag complex formation, simple washing after complex attachment to sperm, high-speed centrifugation, or attempting to separate the ASA-Ag complex by changing the pH value can only result in Irreversible sperm damage and decreased vitality. So when