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作者应用免疫组化技术，检测４７例胰腺癌组织中ｎｍ２３基因产物ＮＤＰＫ的表达，以探讨ｎｍ２３基因与胰腺癌病理特征及生物学行为的关系。结果：４７例胰腺癌ＮＤＰＫ阳性率为５９．６％（２８／４７）。组织学为Ⅰ级的病例ＮＤＰＫ阳性率（７３．３％）明显高于Ⅲ级者（４１．７％，Ｐ＜０．０５）；无淋巴结转移者ＮＤＰＫ阳性率高于有转移者（分别为８０．８％和３３．３％），有非常显著性差异（Ｐ＜０．０１）；ＮＤＰＫ表达阳性者术后１年生存率为２５．０％，而阴性者为０，有显著性差异（Ｐ＜０．０５）；ＮＤＰＫ阳性率与胰腺癌病理类型无关（Ｐ＞０．０５）。结果表明：ｎｍ２３基因对胰腺癌转移具有抑制作用，ＮＤＰＫ表达状况可反映胰腺癌的分化程度及生物学行为。
Using immunohistochemical techniques, the authors examined the expression of nm23 gene product NDPK in 47 cases of pancreatic cancer to explore the relationship between nm23 gene and the pathological features and biological behavior of pancreatic cancer. Results: The positive rate of NDPK in 47 cases of pancreatic cancer was 59.6% (28/47). The positive rate of NDPK in patients with grade I histology (73.3%) was significantly higher than that in patients with grade III (41.7%, P<0.05); the positive rate of NDPK in patients without lymph node metastasis was higher than those with metastasis (respectively 80.8% and 33.3%) had very significant differences (P<0.01); NDPK positive patients showed a 1-year survival rate of 25.0%, while negative patients had 0, with significant differences. (P<0.05); The positive rate of NDPK has nothing to do with the pathological type of pancreatic cancer (P>0.05). The results showed that: nm23 gene has an inhibitory effect on the metastasis of pancreatic cancer. The expression of NDPK can reflect the degree of differentiation and biological behavior of pancreatic cancer.