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目的 研究长期接触低浓度环氧丙烷 (PO)对职业人群的遗传毒性。方法 对PO作业现场进行环境监测的同时 ,采集接触组和对照组工人的血样 ,采用3 2 P后标记法和N alkylEdman气质谱法对DNA加合物 (1-HP -腺嘌呤 )和血红蛋白加合物 (HP -缬氨酸 )含量进行了检测和分析。结果 PO车间两个岗位作业工人PO时间加权平均浓度 (TWA)分别为 2 6mg/m3 和 6 9mg/m3 ;PO接触组工人的DNA加合物水平高于对照组 ,差异有非常显著性 (P =0 0 0 12 ) ;血红蛋白加合物水平也明显高于对照组 ,差异有非常显著性 (P =0 0 0 18) ;DNA加合物与血红蛋白加合物量呈正相关 (r =0 882 ) ;差异有非常显著性 (P <0 0 1)。结论 长期接触低浓度PO对职业人群具有细胞遗传学毒性。
Objective To investigate the genotoxicity of long-term exposure to low-concentration propylene oxide (PO) to occupational populations. Methods The blood samples of workers in the contact group and the control group were collected at the same time as the environmental monitoring of PO site. The DNA adducts (1-HP-adenine) and hemoglobin The content of compound (HP - valine) was detected and analyzed. Results The PO time-weighted average concentration (TWA) of workers in two positions in the PO plant was 26 mg / m3 and 69 mg / m3, respectively. The levels of DNA adducts in workers in the PO-exposed group were significantly higher than those in the control group = 0 0 0 12). The level of hemoglobin adduct was also significantly higher than that of the control group (P = 0.0018). DNA adduct was positively correlated with the amount of hemoglobin adduct (r = 0 882) ; The difference was significant (P <0.01). Conclusion Long-term exposure to low concentrations of PO is cytogenetically toxic to the occupational population.