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近年来病毒学和相关学科的迅速发展,为发展新疫苗提供了良好的条件,许多新的研究成果和设想应运而生.本文就这方面的新动向作一简介.带有中和抗原位点的病毒蛋白在原核细胞中表达用基因工程方法在原核细胞中大规模生产胰岛素、干扰素、生长激素和其他比较简单多肽的研究所取得的成功,促使人们用类似方法生产病毒蛋白.然而遗憾的是至今尚未取得很大成功,主要原因是多肽物质的生物学活性至少是由多肽链本身的氨基酸序列及其空间构象两重因素决定的.尽管已对许多病毒抗原决定簇基因定位有了较详细了解,然而在结构、功能和合成上可能跟激素
In recent years, the rapid development of virology and related disciplines has provided good conditions for the development of new vaccines, and many new research results and ideas came into being.In this paper, a brief introduction of new trends in this area with neutralizing antigenic sites Of viral proteins in prokaryotic cells The success of genetically engineered methods of large-scale production of insulin, interferon, growth hormone, and other relatively simple polypeptides in prokaryotic cells has led to similar attempts to produce viral proteins. Is not yet successful, mainly because the biological activity of the polypeptide is determined by at least two factors: the amino acid sequence of the polypeptide chain itself and its spatial conformation .Although many viral epitopes have been mapped in more detail Understand, however, that the structure, function, and synthesis may be related to hormones