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[目的]探讨贲门癌患者经全胃切除术后临床疗效。[方法]将2005年6月至2012年6月入住本院的120例贲门癌患者随机地均分为对照组与观察组，各为60例。对照组采用近端胃大部切除术进行治疗，观察组采用全胃切除术进行治疗，比较两组术后疗效、两年无进展生存期（PFS ）、术后半年与1年胃肠道症状评分（GSRS）及生活质量等。[结果]①对照组总有效率（PR＋CR）为31．7％（19/60），明显低于观察组治疗总有效率（58．3％，35/60），二者具有显著的统计学差异（P＜0．01）；②PFS ：对照组为（9．66±0．83）个月，观察组为（13．21±0．59）个月，差异具有统计学意义（ P ＜0．05）；③术后半年及1年GSRS评分：对照组分别为（3．3±0．6）分、（2．5±0．4）分，观察组分别为（6．5±1．2）分、（5．1±0．8）分，二组差异均具有统计学意义（均 P ＜0．05）；④根据QLQC-30生活质量评价标准，对照组与观察组术后生活质量差异具有统计学意义（ P ＜0．05）。[结论]全胃切除术能够提高贲门癌近期疗效、两年无进展生存期以及术后患者的短期生活质量，改善患者胃肠道症状，应加以推广并应用。“,”[Objective]To explore the clinical efficacy of total gastrectomy for patients with cardia cancer .[Methods] Totally 120 patients with cardia cancer in our hospital from June 2005 to June 2012 were randomly divided into control group and observation group with 60 patients in each group .The control group underwent proximal gastrectomy ,while the observation group underwent total gastrectomy .The efficacy ,two-year pro-gression-free survival(PFS) ,gastrointestinal symptom score (GSRS) at half a year and one year after opera-tion and quality of life were compared between two groups .[Results] The total effective rate (PR+ CR) in control group was 31 .7% (19/60) ,which was obviously lower than that in observation group (58 .3% ,35/60) ,and there was significant difference between two groups ( P<0 .01) .PFS of the control group and obser-vation group were (9 .66 ± 0 .83) and (13 .21 ± 0 .59) months ,respectively ,and there was significant differ-ence( P <0 .05) .GSRS scores in control group and observation group at half a year and one year after opera-tion were (3 .3 ± 0 .6) ,(2 .5 ± 0 .4) ,(6 .5 ± 1 .2) and (5 .1 ± 0 .8) respectively ,and there were significant differences between two groups(all P<0 .05) .According to QLQC-30 quality of life evaluation criteria ,there was significant difference in postoperative quality of life between control group and observation group ( P <0 .05) .[Conclusion]Total gastrectomy can increase the short-term efficacy ,two-year progression-free survival and short-term quality of life and improve gastrointestinal symptoms of patients with gastric cardia cancer . Therefore ,it should be promoted and applied .