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自体髂骨移植在临床普遍被采用,脱钙的骨基质被普遍认为能促进骨修复。Urist从脱钙骨中成功地提取了骨形态发生蛋白,应用于刺激动物因手术所致节段性缺损的修复。失活的培养的人骨肉瘤细胞系(saos-2)的提取物能诱导骨形成。本研究旨在评估Saos-2细胞半提纯提取物促进长骨不愈模型骨愈合的能力。40只成年雄鼠随机分成4组,每组10只。组Ⅰ(对照组)无试验材料置入骨缺损处;组Ⅱ缺损处用纯牛胶原充填;组Ⅲ用股骨切除部分作自体移植物植入缺损处;组Ⅳ用从Saos-2细
Autogenous iliac bone grafts are commonly used in clinics, and decalcified bone matrix is generally considered to promote bone repair. Urist successfully extracted bone morphogenic proteins from decalcified bone and used it to stimulate the repair of segmental defects caused by surgery. Extracts of inactivated cultured human osteosarcoma cell lines (saos-2) can induce bone formation. The aim of this study was to evaluate the ability of semi-purified extracts of Saos-2 cells to promote bone healing in long bone unhealed models. Forty adult male rats were randomly divided into 4 groups with 10 animals in each group. Group I (control group) no test material was placed into the bone defect; group II defect was filled with pure bovine collagen; group III was autografted with the femur resection part implanted defect; group IV was used from Saos-2 fine