Objective: Smal intestinal tumors (SBTs) were dif icult to be discovered before surgery. The emergence of dou-ble-bal oon enteroscopy (DBE) and capsule endoscopy (CE) have greatly improved the evaluation of SBTs and facilitated a more precise preoperative diagnosis. Yet little data exist in China regarding clinical ef icacy of DBE and clinical characteristics of SBTs. The aim of our study was to clarify the clinical characteristics of SBTs and analyze the ef icacy of DBE examination in the detection and diagnosis of SBTs. Methods: We retrospectively reviewed patients who underwent DBE in our hospital between June 2011 and July 2014. Patients who were diagnosed with SBTs by DBE were included in the study. Results: A total of 316 patients underwent 321 DBE procedures, 80 (25.3%) of whom were suspected to have an SBT. And 59 of the 80 subjects were diagnosed with SBT final y. The majorities (59.3%, 35/59) of the patients diagnosed with SBT were males, whose average age was 61.8 years (SD ±11.0 years). DBE were frequently performed in patients with obscure gastrointes-tinal bleeding (66.1%), abdominal pain (16.9%). The common SBTs identified were: gastrointestinal stromal tumors (GISTs) (24/59, 40.7%), adenocarcinomas (13/59, 22.0%), lymphomas (6/59, 10.2%) and benign polyps (6/59, 10.2%). Jejunum had the highest detection rate (47.5%, 29/61). During the fol ow-up period (3 months to 3 years), 14 patients were submitted to chemotherapy and two patients died of tumor. Conclusion: The most high frequency type and location of SBTs detected in our hospital were dif erent from western countries. DBE is a valuable and safe examination for SBTs.