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已有报道,药物-PVP共沉淀体能大大增加药物的溶出速率,并证明药物的无定形态是其溶出速率增加的支配因素。在此基础上,作者探讨了应用共沉淀技术增加磺胺噻唑(ST)和氢化可的松(HC)膜转运的可能性。ST和HC的PVP共沉淀体都是用乙醇蒸去法制得。膜转运扩散池是由两个透明的、体积为40ml的园
It has been reported that drug-PVP co-precipitates can greatly increase the dissolution rate of the drug and demonstrate that the amorphous state of the drug is the dominant factor in the increase of its dissolution rate. On this basis, the authors explored the possibility of using coprecipitation techniques to increase the transport of sulfathiazole (ST) and hydrocortisone (HC) membranes. The PVP coprecipitates of ST and HC are prepared by steam distillation of ethanol. Membrane transport diffusion cell is composed of two transparent, volume 40ml garden