[目的]研究吡蚜酮原药对大鼠的胚胎毒性和致畸作用。[方法]按照GB 15670—1995《农药登记毒理学试验方法》应用SpragueDawley大鼠进行致畸毒性试验,设40、120、360mg/kg三个剂量组、玉米油阴性对照组和135mg/kg全反式维甲酸阳性对照组,给药时间为大鼠妊娠后第6~15天。[结果]以360 mg/kg经口饲喂Sprague Dawley妊娠大鼠,妊娠大鼠的体质量增长缓慢,但对胎鼠无影响。[结论]吡蚜酮原药无胚胎毒性和致畸作用。 [Objective] To study the embryotoxicity and teratogenic effects of pymetrozine in rats. [Method] Teratogenicity toxicity test was carried out in Sprague Dawley rats according to GB 15670-1995 “Toxicological Test of Pesticide Registration”. Three dose groups of 40, 120 and 360 mg / kg, corn oil negative control group and 135 mg / kg total anti- Retinoic acid-positive control group, the administration time of 6 to 15 days after pregnancy in rats. [Result] Sprague Dawley pregnant rats were orally fed with 360 mg / kg. The body weight of pregnant rats increased slowly but had no effect on fetal rats. [Conclusion] The pymetrozine drug has no embryo toxicity and teratogenicity.