以胞嘧啶单核苷酸酶（CMP）作为溶酶体的细胞代学标志酶，观察急性乙醇中毒鼠心肌细胞溶酶体和线粒体被溶酶体降解的形态变化；结果显示；多数线粒体肿胀，部分外膜溶解、破损，嵴断裂、溶解、消失，被溶酶体包围、侵入，形成空泡；肌原纤维也有不同程度损伤。作者推断：急性乙醇中毒时，线粒体的病理性损伤是造成心肌和传导系功能障碍的重要原因。 Cytosine mononucleotidase (CMP) was used as lysosomal cytology marker enzyme to observe the morphological changes of lysosomes and mitochondria lysosomes in acute alcohol-poisoned rat myocardium. The results showed that most mitochondria were swollen, Some of the outer membrane is dissolved, damaged, broken cristae, dissolved, disappeared, surrounded by lysosomes, invaded, the formation of vacuoles; myofibrils also have varying degrees of damage. The authors conclude that in acute alcoholism, the pathological damage of mitochondria is an important cause of dysfunction in the myocardium and the conduction system.