论文部分内容阅读
目的：研究静脉补充左旋卡尼汀对维持性血液透析患者肉碱缺乏症的治疗作用。方法：采用多中心、双盲、随机、对照的研究方法，选择血透患者１９７例，分为治疗组、对照组和开放组，治疗组和开放组静脉注射左旋卡尼汀１ｇ，２～３次／周×３月，对照组注射生理盐水。结果：治疗组和开放组体力、精神状态、食欲、恶心、呕吐、透析耐受性、透析中肌痉挛或低血压等症状的改善十分显著，血浆肉碱浓度明显升高，对照组以上各项均无变化，治疗组与对照组相比差异十分显著；治疗组及开放组血浆总蛋白、白蛋白、前白蛋白和转铁蛋白等营养参数也有不同程度的升高。主要不良反应为转氨酶轻度升高和血小板降低，发生率分别为５．３％和２．３％，停药后即可恢复正常。结论：左旋卡尼汀注射液治疗慢性肾衰维持血透患者肉碱缺乏症安全、而且有效
Objective: To study the therapeutic effect of intravenous levocarnitine on carnitine deficiency in maintenance hemodialysis patients. METHODS: A total of 197 hemodialysis patients were divided into treatment group, control group, open group, treatment group and open group by intravenous injection of levocarnitine 1g, 2 ~ 3 Times / week × March, the control group injected with saline. Results: The improvement of physical, mental state, appetite, nausea, vomiting, dialysis tolerance, muscle spasms or hypotension in dialysis group were significant and plasma carnitine concentrations were significantly increased in the treatment group and the open group. The above items in the control group There was no significant difference between the treatment group and the control group. The nutritional parameters of total protein, albumin, prealbumin and transferrin in the treatment group and the open group also increased to some extent. The main adverse reactions were mild transaminase and thrombocytopenia, the incidence rates were 5.3% and 2.3%, respectively, after withdrawal can be returned to normal. Conclusion: L-carnitine injection in patients with chronic renal failure to maintain carnitine deficiency in patients with hemodialysis safety, and effective