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Objective: To test the expression of HER4 in non-small cell lung cancer(NSCLC)and elucidate the relationship between its over-expression and the clinical pathology of NSCLC.Methods: 70 cases of paraffin-embedded tissues from informative NSCLC were tested for the expression of HER4 by means of immunohistochemical assay.Results: HER4 were overexpressed in NSCLC in 91.4%.The overexpression of HER4 correlated only with the lymph node metastasis, TNM staging and survival after operation.Conclusion: ErbB4 is one of the genes to regulate the growth of NSCLC in advanced stages and artificial interference of the overexpression of HER4 in NSCLC might be a good way for the treatment of NSCLC in advanced stages.