NF κB是一个广泛存在于哺乳动物细胞中的转录因子。它可以参与机体的炎症反应、免疫反应、细胞分化与凋亡及其他应激反应。NF κB启动基因的表达涉及到IKK的激活、IκB磷酸化和泛素化、IκB裂解、NF κB向核内的迁移、NF κB与DNA的结合等过程。NF κB的过度激活会引起一系列的疾病 ,如哮喘、类风湿性关节炎、肠炎等 ,利用药物或通过转基因方法来抑制以NF κB为核心的信号转导途径可能会成为防治某些疾病的途径。 NF κB is a transcription factor widely found in mammalian cells. It can participate in the body’s inflammatory response, immune response, cell differentiation and apoptosis, and other stress reactions. The expression of NF-κB promoter involves the activation of IKK, phosphorylation and ubiquitination of IκB, the cleavage of IκB, the migration of NFκB into the nucleus, the binding of NFκB to DNA, and so on. NF κB over-activation can cause a series of diseases such as asthma, rheumatoid arthritis, enteritis, etc., using drugs or by genetically modified to inhibit NF κB as the core of the signal transduction pathway may become the prevention and treatment of certain diseases way.