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β2受体激动剂的滥用威胁着消费者的人身安全,也制约着食品工业和畜牧业的发展,然而药物种类繁多,更新迅速,如何对其有效监测一直是研究的重点小分子RNA(miRNA)是近年来在真核生物体内发现的一类长度约22个核苷酸的内源性非编码单链RNA,主要通过与靶基因rmRNA靶标区域的互补配对,发挥降解靶rmRNA或抑制mRNA翻译的作用.它能参与多种生物学过程包括细胞凋亡、分化和癌变等.β2受体激动剂类药物有着共同的作用机理,近年来的研究表明,miRNA的异常表达与β2受体激动剂的使用密切相关.本文主要对与β2受体激动剂作用机理相关的miRNA的研究进展展开综述,以期为实现对该类药物的有效监测提供参考.“,”The abuse of β2-agonist threatens the safety of consumers,restricting the development of the food industry and animal husbandry.However,β2-agonists include a wide range of drugs which update quickly,and an effective monitoring has been the focus and difficulties.MiRNAs (microRNAs) are a class of non-coding single-stranded RNAs about 22 nucleotides in length found in eukaryotes.They are complementary to each other in the targeted region of target miRNA,degrading target miRNA or inhibit the translation of miRNA.It can participate in a variety of biological processes,including apoptosis,differentiation and cancer.β2-agonists have a common action mechanism,and recent studies have shown that the abnormal expression of miRNAs are closely related to the use of β2-agonists.In this paper,the progress of miRNAs related to the mechanism of β2-agonists is reviewed in order to provide a reference for effectively monitoring.