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人类的脑组织损伤后不能再生,常留下神经机能丧失。为探索脑组织的机能恢复,自1976年起,瑞典卡洛林斯卡、美国科罗拉多、英国剑桥等三所大学的Bjoklund,Stenevi,Olson,Hoffer,Gash Iversen等人先后开展了脑组织移植的实验研究。他们在大白鼠的脑内或眼前房内移植胚胎鼠的皮层、蓝斑、黑质、视上核附近的下丘脑等组织块,发现移植物能长久成活、生长或分泌相应的神经递质,使动物的神经机能缺失得到纠正。特别是近年对破坏一侧黑质,引起纹状体内的多巴胺含量减少,动物发生行为改变,然后移植胚胎黑质进行治疗的研究更多。
Human brain tissue damage can not be regenerated, often leaving the loss of nerve function. In order to explore the functional recovery of brain tissue, Bjoklund, Stenevi, Olson, Hoffer, Gash Iversen and others from three universities in Karolinska, Sweden, Colorado, and Cambridge in England conducted experiments on brain tissue transplantation since 1976 the study. They transplanted the cortex, locus coeruleus, substantia nigra and the hypothalamus near the supraoptic nucleus in rat’s intracranial or anterior chamber and found that the graft can survive, grow or secrete corresponding neurotransmitters for a long time, So that the lack of nerve function of animals be corrected. Especially in recent years, the destruction of one side of the substantia nigra, causing decreased striatum dopamine content, animal behavior changes, and then transplantation of embryonic substantia nigra for treatment more.