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目的 :了解肠球菌所致感染的概况及其对抗菌药的敏感性。方法 :调查与分析复旦大学附属华山医院 1998年 6月～1999年 3月临床分离获肠球菌住院患者的临床资料 ,用KB法测定细菌药敏。结果 :116例患者中 ,属医院感染、院外感染者分别为 37和 13例 ,带菌者 6 6例 ,感染部位多为尿路 (6 4% )、次为腹腔 (18% ) ,粪肠球菌 (6 4% )多于屎肠球菌 (36 % )。患严重基础疾病、接受介入诊疗操作、应用广谱抗菌药可能是肠球菌医院感染的危险因素。药敏结果显示 :氨苄西林、万古霉素对肠球菌抗菌活性相对较高 ,抑菌率分别为 75 .8%和 96 .9% ,屎肠球菌耐药率高于粪肠球菌。结论 :肠球菌已成为医院感染患者主要病原菌之一 ,及时、合理诊治是治愈该类感染的关键。
Objective: To understand the general situation of enterococcal infection and its sensitivity to antibacterials. Methods: The clinical data of hospitalized enterococci in Huashan Hospital Affiliated to Fudan University from June 1998 to March 1999 were investigated and analyzed. The drug susceptibility of bacteria was determined by KB method. Results: Of the 116 patients, 37 were hospital-acquired and 13 were hospital-acquired, 6 of which were carriers of infection. Most of the infected patients were urinary tract (64%), followed by abdominal cavity (18%), Enterococcus faecalis (64%) than Enterococcus faecium (36%). Suffering from serious underlying diseases, interventional diagnosis and treatment operations, the application of broad-spectrum antimicrobial agents may be enterococci nosocomial infection risk factors. Drug susceptibility results showed that ampicillin and vancomycin had relatively higher antibacterial activity against enterococci, with antibacterial rates of 75.8% and 96.9%, respectively. Enterococcus faecium was more resistant than Enterococcus faecalis. Conclusion: Enterococcus has become one of the main pathogenic bacteria in nosocomial infections, and timely and reasonable diagnosis and treatment is the key to cure such infections.