目的 :分析慢性前列腺炎 (chronicprostatitis ,CP)致病菌及复合药敏试验规律 ,探索治疗方法。方法 :对30 0例无菌采集的前列腺液 (EPS)标本同时接种需氧菌 ,厌氧菌、L型菌培养基鉴定并做药敏试验。结果 :表皮葡萄球菌 (5 8.3% )、丙酸杆菌 (2 9.3 % )为CP致病的两大优势菌 ;二者在致病过程中具有协同作用 ;表皮葡萄菌随年龄增大而感染率降低 ,三组间有显著性差异 (P <0 .0 5 ) ,L型菌是疾病复发、难以治愈的原因之一 ;治疗首选利福平、氟哌酸而青霉素、洁霉素几乎是无效的。结论 :多种形式的细菌检测和复合药敏试验是非常必要的 ,目前尚无他法替代 OBJECTIVE: To analyze the pathogenesis of chronic prostatitis (CP) and the drug susceptibility test and explore the therapeutic methods. Methods: A total of 300 specimens of prostatic fluid (EPS) collected from asepsis were inoculated simultaneously with aerobic, anaerobic, and L-type bacterial cultures and drug-susceptibility tests. Results: Staphylococcus epidermidis (5 8.3%) and Propionibacterium acnes (2 9.3%) were two predominant bacteria of CP pathogenicity. Both of them had synergistic effect during pathogenicity. The infection rate of Staphylococcus epidermidis with age increased (P <0.05), L-type bacteria is one of the causes of disease recurrence, which is difficult to cure; the treatment of choice of rifampin, norfloxacin and penicillin, lincomycin almost ineffective of. Conclusions: Various forms of bacterial testing and composite susceptibility testing are necessary and there is no alternative