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骨髓增生异常综合征(MDS)为非均一性克隆性造血干细胞失常。常进展为急性白血病。抗白血病治疗见效者甚少。易因骨髓持续再生障碍引起感染和出血死亡。按照FAB协作组分类,MDS可分为5个亚型,包括难治性贫血(RA)、伴环形铁粒幼细胞的难治性贫血(RARS)、原始细胞过多性难治性贫血(RAEB)、转化中的RAEB(RAEBt)及慢性粒-单核细胞白血病(CMML)。
Myelodysplastic syndrome (MDS) is a heterogeneous clonogenic hematopoietic stem cell disorder. Often progress to acute leukemia. Anti-leukemia treatment is very effective. Easily due to persistent bone marrow regeneration infection and bleeding deaths. According to the FAB collaborative group classification, MDS can be subdivided into five subtypes, including refractory anemia (RA), refractory anemia with ring-shaped myeloid granulocytes (RARS), and paranodular refractory anemia (RAEB ), Transforming RAEB (RAEBt), and chronic myelomonocytic leukemia (CMML).