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目的观察比较莫沙比利联合乳果糖口服溶液治疗帕金森症便秘疗效及安全性。方法将64例患者按随机、双盲法分为治疗组和对照组各32例,对照组用乳果糖口服溶液15ml/次,晨起1次口服,疗程2周。治疗组用乳果糖口服溶液15ml/次,晨起1次口服;同时口服莫沙比利5mg,3次/次,疗程2周。2周后观察患者治疗情况和药物不良反应。结果治疗组总有效率为81.3%明显高于对照组的56.3%,2组比较差异有统计学意义(P<0.05)。结论乳果糖口服溶液联合莫沙比利治疗帕金森患者便秘比单独使用乳果糖口服溶液疗效更确切。
Objective To compare the efficacy and safety of mosapride and lactulose oral solution in the treatment of Parkinson’s disease constipation. Methods Sixty-four patients were randomly divided into treatment group and control group, 32 cases in each group. The control group was orally administered with lactulose 15ml once daily for 2 weeks. Treatment group with lactulose oral solution 15ml / time, early morning 1 oral; at the same time oral mosapride 5mg, 3 times / times for 2 weeks. Two weeks later, the patient’s treatment and adverse drug reactions were observed. Results The total effective rate was 81.3% in the treatment group was significantly higher than 56.3% in the control group, the difference between the two groups was statistically significant (P <0.05). Conclusion lactothrix oral solution combined with mosapride in patients with Parkinson’s disease constipation than the lactose solution alone more effective oral solution.