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目的:分析本院2006年8月～2008年8月间286例血清茶碱浓度监测结果。方法:利用荧光偏振免疫法测定血清茶碱浓度。结果:大部分患者血药浓度处于5～15μg·ml~(-1)范围内,且随着患者年龄的增加,血药浓度值增大;而血药浓度值越大,不良反应发生率越高。结论:应根据患者基本情况,个体化使用茶碱类药物,并监测血药浓度,使茶碱类药物得到更安全、合理、有效的应用。
Objective: To analyze the results of 286 serum theophylline concentrations in our hospital from August 2006 to August 2008. Methods: The serum theophylline concentration was determined by fluorescence polarization immunoassay. Results: The plasma concentration of most patients was in the range of 5 ~ 15μg · ml ~ (-1), and the plasma concentration increased with the increase of the patient’s age. The higher the plasma concentration, the more the adverse reaction rate high. Conclusion: According to the basic situation of patients, theophylline drugs should be used individually and the plasma concentration should be monitored to make theophylline drugs more safe, reasonable and effective.