在60年代,人们已经注意到与先天性免疫缺陷有关恶性肿癌的发病率很高。此后的10年中,人们在接受异体器官移植的患者中发现该恶性肿瘤尤其是淋巴肿瘤重新频繁出现。最近研究证实,HIV感染和接受某些骨髓移植的病人更易患淋巴肿瘤。目前人们已弄清楚,由免疫缺陷(无论是先天性的、医源性的,还是获得性的)所导致发展而成的淋巴肿瘤均有一个独特的临床病理学表现,它在病因和临床表现上都与有正常免疫力病人的非何杰金氏淋巴瘤截然不同,此类肿瘤中的大多数均与EBV In the 1960s, it has been noted that the incidence of malignant tumors associated with congenital immunodeficiency is high. The next 10 years, people in allogeneic organ transplant recipients found that the malignant tumor, especially lymphoma recurrence frequently. Recent research confirms that HIV infection and those receiving certain bone marrow transplants are more susceptible to lymphoma. It has now been clarified that lymphomas, which result from the development of immunodeficiencies (whether congenital, iatrogenic, or acquired), have a unique clinicopathological manifestation of etiology and clinical manifestations Are distinctly different from non-Hodgkin’s lymphoma in patients with normal immunity, the majority of these tumors are associated with EBV