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目的检测喉鳞癌组织中T-钙黏蛋白(T-cadherin)的表达情况,探讨T-cadherin与喉鳞癌临床病理特征的关系。方法采用免疫组化检测55例喉鳞癌组织和55例癌旁组织中T-cadherin的表达,并结合临床病理特征进行分析。结果 T-cadherin在癌旁组织阳性表达率为87.27%,而在喉鳞癌组织中的阳性表达率仅为30.91%,经χ2检验,差异有统计学意义(P<0.01)。T-cadherin在喉鳞癌组织中的表达情况与肿瘤分化和颈淋巴结转移、TNM分期呈负相关。结论在喉鳞癌组织中存在T-cadherin的表达缺失或低水平表达,提示T-cadherin在喉鳞癌的发生、发展和转移中起着重要的作用。
Objective To detect the expression of T-cadherin in laryngeal squamous cell carcinoma and to explore the relationship between T-cadherin and the clinicopathological features of laryngeal squamous cell carcinoma. Methods Immunohistochemistry was used to detect the expression of T-cadherin in 55 cases of laryngeal squamous cell carcinoma and 55 cases of paracancerous tissues, and to analyze the clinicopathological features. Results The positive rate of T-cadherin in paracancer tissues was 87.27%, while it was only 30.91% in laryngeal squamous cell carcinoma tissues. The difference was statistically significant (P <0.01) by χ2 test. T-cadherin expression in laryngeal squamous cell carcinoma and tumor differentiation and cervical lymph node metastasis, TNM stage was negatively correlated. Conclusion The lack or low expression of T-cadherin in laryngeal squamous cell carcinoma suggests that T-cadherin plays an important role in the development, metastasis and metastasis of laryngeal squamous cell carcinoma.