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[目的]了解新生儿邻苯二甲酸酯(PAEs)宫内暴露的质量浓度(后称“浓度”),并探索其与新生儿性激素或甲状腺激素水平的关联。[方法]收集新生儿胎粪并检测胎粪中常见PAEs的代谢物,收集脐带血并检测游离睾酮(FT)、总四碘甲状腺素(T4)等常见性激素指标和甲状腺激素指标,并采用线性回归方法分析两者间的关系。[结果]新生儿胎粪中检出的代谢物主要是邻苯二甲酸单乙基己酯(MEHP)、邻苯二甲酸单正丁酯(Mn BP)和邻苯二甲酸单异丁酯(Mi BP),检出率分别为100%、99%和99%。男性新生儿雌二醇(E2)水平与邻苯二甲酸单甲酯(MMP)(b=2.44,P=0.027)、Mn BP(b=4.08,P=0.044)及Mi BP(b=3.89,P=0.003)呈正相关,FT与MEHP(b=4.42,P=0.049)呈正相关;女性新生儿性激素水平与各PAEs代谢物浓度未见关联。除男性促甲状腺激素(TSH)与邻苯二甲酸单乙酯(MEP)浓度(b=0.40,P=0.015)呈正相关外,新生儿甲状腺激素其余指标与PAEs浓度均未见关联。[结论]新生儿宫内暴露于PAEs与新生儿的性激素水平变化可能存在一定的关联。
[Objective] To understand the intrauterine exposure mass concentration (hereinafter referred to as “concentration”) of neonatal phthalates (PAEs) and to explore its association with neonatal sex hormone or thyroid hormone levels. [Methods] Neonatal meconium was collected and the metabolites of common PAEs in meconium were detected. Cord blood was collected and the common hormones such as free testosterone (FT), total tetraiodothyronine (T4) and thyroid hormones were measured. The linearity Regression method to analyze the relationship between the two. [Results] The metabolites detected in neonatal meconium were mainly monoethylhexyl phthalate (MEHP), mono-n-butyl phthalate (Mn BP) and monoisobutyl phthalate Mi BP), the detection rates were 100%, 99% and 99% respectively. Male neonates had significantly lower estradiol (E2) levels compared with those with monomethyl phthalate (bM = 2.44, P = 0.027), Mn BP (b = 4.08, P = 0.044) P = 0.003). There was a positive correlation between FT and MEHP (b = 4.42, P = 0.049). There was no correlation between sex hormones and metabolites of PAEs in female neonates. Except for the positive correlation between TSH and MEP concentrations (b = 0.40, P = 0.015), there was no correlation between neonatal thyroid hormone and other PAEs. [Conclusion] There may be some correlation between neonatal intrauterine exposure to PAEs and neonatal sex hormone levels.