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目的：探讨喉鳞状细胞癌中Ｐ１６蛋白表达的情况及临床相关性。方法：用免疫组化的方法检测４２例喉鳞癌组织中Ｐ１６蛋白的表达情况。结果：Ｐ１６蛋白表达的阳性率为４７．６２％（２０／４２）。其中声门上型组为４０．００％（４／１０），声门型组为５７．８９％（１１／１９），声门下型组为３８．４６％（５／１３）；细胞分化Ⅰ级组为７５．００％（１２／１６），Ⅱ～Ⅲ级组为３０．７７％（８／２６）；伴有颈淋巴结转移组为２０．００％（３／１５），无颈淋巴结转移组为６２．９６％（１７／２７）；临床Ⅰ期组为４０．００％（８／２０），Ⅱ～Ⅳ期组为５４．５４％（１２／２２）。结论：提示Ｐ１６蛋白的表达与癌细胞的分化程度及肿瘤的转移情况有关，与临床分型及分期无关。
Objective: To investigate the expression and clinical significance of P16 protein in laryngeal squamous cell carcinoma. Methods: The expression of P16 protein in 42 cases of laryngeal squamous cell carcinoma was detected by immunohistochemistry. Results: The positive rate of P16 protein expression was 47.62% (20/42). Among them, 40.00% (4/10) in the supraglottic group, 57.89% (11/19) in the glomerular gland type and 38.46% (5/13) in the supraglottic type; 75.00% (12/16) in grade group, 30.77% (8/26) in grade Ⅱ ~ Ⅲ group, 20.00% (3/15) in cervical lymph node metastasis group, no lymph node metastasis Group was 62.96% (17/27). The clinical stage Ⅰ group was 40.00% (8/20), while the stage Ⅱ ~ Ⅳ group was 54.54% (12/22). Conclusion: The expression of P16 protein is related to the differentiation degree of tumor cells and tumor metastasis, but not to clinical classification and stage.