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扁平苔藓特别是口腔损害,通常治疗顽固。本文报道曾用常规治疗无效的2例扁平苔藓对口服13顺式维甲酸(isotretinoin)的疗效。例1:51岁白人妇女,患皮肤扁平苔藓4年。8个月前出现严重的口腔糜烂及吞咽疼痛。皮肤及粘膜损害外用类同醇激素无效。粘膜损害对利多卡因、维甲酸外用,苯海拉明、四环素口腔灌洗无效。强的松40mg/d治疗3周后,口腔损害改善50%。当减量至5mg/d时,疾病复发如故。采用13顺式维甲酸0.5mg/kg治疗,
Lichen planus, especially oral damage, usually treats stubbornness. This article reports the efficacy of oral administration of 13 isotretinoin in two cases of lichen planus that had been ineffective with conventional therapy. Example 1: 51-year-old white woman, suffering from lichen planus 4 years. 8 months ago, severe oral erosion and swallowing pain. Skin and mucosal damage to the same class of alcohol-like hormone is invalid. Mucosal damage to lidocaine, retinoic acid topical, diphenhydramine, tetracycline oral lavage invalid. Prednisone 40mg / d after 3 weeks of treatment, oral lesions improved by 50%. When the reduction to 5mg / d, the recurrence of the disease as before. Using 13 cis retinoic acid 0.5mg / kg treatment,