报告一例掌跖纤维瘤病。患者女，３１岁，皮损主要发生于双手掌、足底，为中指、无名指与远端掌横纹交界处的坚实的结节融合成条索状的斑块。病理活检示纤维组织结节样增生，免疫组化示ＴＧＦβ１阴性，极个别细胞阳性。该患者尿酸水平增高，关节面破坏，伴发痛风。对掌跖纤维瘤病的临床病理特点、超微结构及与发病有关的细胞因子进行了文献复习。 A case of palmar fibromatosis was reported. The female patient, 31 years old, suffered skin lesions that mainly occurred in the palms and soles of the hands. The solid nodules at the junction of the middle finger and ring finger with the distal palm striations merged into a cord-like plaque. Pathological biopsy showed fibrous nodular hyperplasia. Immunohistochemistry showed negative TGF-β1, and very few cells were positive. The patient’s uric acid levels increased, the articular surface was destroyed, and gout was associated. The literature review of the clinicopathological features, ultrastructure, and cytokines associated with pathogenesis of palmoplantar fibromatosis was conducted.