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目的观察早期应用微生态制剂辅助治疗新生儿黄疸的临床效果。方法选取2013年6月-2015年6月该院收治的125例新生儿黄疸患儿,将其随机分为实验组和对照组。对照组59例,选用常规蓝光照射;实验组66例,在对照组的基础上早期应用微生态制剂。观察并比较两组的临床治疗效果及不良反应发生率。结果实验组治疗新生儿黄疸有效率(93.94%)明显高于对照组(86.44%),实验组黄疸减退时间平均为(38.13±3.91)h,明显低于对照组的(43.97±4.56)h,实验组治疗72 h后经皮胆红素较治疗前下降,平均为(138.26±30.15)μmol/L,明显低于对照组,差异均有统计学意义(P<0.05);实验组和对照组不良反应发生率均较低,虽实验组不良反应发生率低于对照组,但差异无统计学意义(P>0.05)。结论早期应用微生态制剂联合蓝光照射辅助治疗新生儿黄疸临床效果显著,黄疸减退速度快,且不增加不良反应的发生率,可积极在临床推广应用。
Objective To observe the clinical effect of early application of probiotics in the treatment of neonatal jaundice. Methods 125 neonates with neonatal jaundice admitted from June 2013 to June 2015 in our hospital were randomly divided into experimental group and control group. Control group, 59 cases, the choice of conventional blue light irradiation; experimental group of 66 cases, based on the control group early application of probiotics. Observed and compared the clinical treatment of two groups and the incidence of adverse reactions. Results The effective rate of jaundice (93.94%) in the experimental group was significantly higher than that of the control group (86.44%), the average time of jaundice subsided in the experimental group was (38.13 ± 3.91) h, which was significantly lower than that of the control group (43.97 ± 4.56) The level of transcutaneous bilirubin in experimental group decreased significantly after treatment for 72 h (138.26 ± 30.15 μmol / L), which was significantly lower than that in control group (P <0.05). The experimental group and control group The incidence of adverse reactions were lower, although the incidence of adverse reactions in the experimental group was lower than that of the control group, but the difference was not statistically significant (P> 0.05). Conclusion Early application of probiotics combined with blue light adjuvant treatment of neonatal jaundice has a significant clinical effect, jaundice reduced rapidly, and does not increase the incidence of adverse reactions, can be actively promoted in the clinical application.