患者 ,男 ,45岁 ,患泛发性白癜风 12年 ,外用氮芥溶液 (浓度不详 ) 8年后 ,白斑处出现较多绿豆大小的角化性丘疹 ,病理示 :高度角化过度伴角化不全 ,棘层肥厚 ,细胞未见明显异形 ,真皮浅层血管周围少量淋巴细胞浸润。近 1年来左手背部在角化性丘疹基础上继发肿块 ,肿块活检 ,病 Patients, male, 45 years old, suffering from generalized vitiligo for 12 years, topical nitrogen mustard solution (unknown concentration) 8 years later, more green beans appear keratinized papules at the white spots, pathology showed: hyperkeratosis accompanied with keratosis Incomplete, acanthosis hypertrophy, no significant abnormal cells, a small amount of dermal perivascular lymphocytes infiltration. In the past 1 year, the back of the left hand had secondary mass, mass biopsy, and disease on the basis of keratosis papules