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目的探讨不同剂量辛伐他汀治疗对血脂异常患者糖代谢的影响。方法选择2014年1~8月来我院接受治疗的血脂异常患者120例,按照数表法随机平均分为A、B、C三组,每组各40例,其中A组患者每天使用辛伐他汀10 mg,B组患者为20 mg,C组患者为40 mg,治疗3个月后比较三组患者治疗后的血脂水平变化和糖代谢情况。结果 1A、B、C三组患者治疗后的低密度脂蛋白胆固醇(LDL-C)分别为(2.83±0.52)mmol/L、(2.72±0.49)mmol/L和(1.71±0.32)mmol/L,差异有统计学意义(P<0.05);高密度脂蛋白胆固醇(HDL-C)分别为(1.26±0.43)mmol/L、(1.32±0.47)mmol/L、(1.36±0.51)mmol/L,差异有统计学意义(P<0.05);总胆固醇(TC)分别为(4.71±0.40)mmol/L、(4.32±0.31)mmol/L、(3.65±0.35)mmol/L,差异有统计学意义(P<0.05);甘油三酯(TG)分别为(1.89±0.63)mmol/L、(1.85±0.61)mmol/L、(1.67±0.29)mmol/L,差异有统计学意义(P<0.05);2治疗后三组患者的糖化血红蛋白与餐前及餐后血糖均轻微升高,胰岛素水平无明显变化,经比较差异均无统计学意义(P>0.05)。结论将辛伐他汀应用于血脂异常患者,剂量与疗效密切相关,较大剂量辛伐他汀具有高效性,但不同剂量辛伐他汀对糖代谢无明显影响。
Objective To investigate the effects of different doses of simvastatin on glucose metabolism in patients with dyslipidemia. Methods A total of 120 patients with dyslipidemia who were treated in our hospital from January to August 2014 were randomly divided into three groups (A, B and C), 40 cases in each group. The patients in group A received daily simulations Statin 10 mg, group B 20 mg, group C 40 mg, after 3 months of treatment compared the three groups of patients after treatment of blood lipid levels and glucose metabolism. Results After treatment, the LDL-C in the three groups were (2.83 ± 0.52) mmol / L, (2.72 ± 0.49) mmol / L and (1.71 ± 0.32) mmol / L (1.26 ± 0.43) mmol / L, (1.32 ± 0.47) mmol / L, (1.36 ± 0.51) mmol / L respectively, and the difference was statistically significant (P 0. 05). The levels of high density lipoprotein cholesterol , The difference was statistically significant (P <0.05). The total cholesterol (TC) were (4.71 ± 0.40) mmol / L, (1.89 ± 0.63) mmol / L, (1.85 ± 0.61) mmol / L and (1.67 ± 0.29) mmol / L, respectively (P <0.05), and the difference was statistically significant (P < 0.05). After 2 treatment, HbA1c slightly increased with pre and postprandial blood glucose, insulin level did not change significantly after treatment (P> 0.05) .3. Conclusion Simvastatin is used in patients with dyslipidemia. The dose and curative effect are closely related to the high dose of simvastatin, but no significant effect of different doses of simvastatin on glucose metabolism.