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勃起功能障碍和下尿路症状之间存在独立相关性。两者的相互影响机制一般认为主要与一氧化氮/一氧化氮合酶的变化、自主神经系统过度活动、RhoA/Rho激酶及内皮素通道的影响和盆腔动脉硬化症四个方面有关。磷酸二酯酶Ⅴ型抑制剂可通过对逼尿肌、尿道及前列腺部平滑肌产生舒张效应从而改善膀胱出口部梗阻,单独应用或联合α-受体阻滞剂能有效改善下尿路患者的症状及生活质量评分,联合应用效果更佳。
There was an independent correlation between erectile dysfunction and lower urinary tract symptoms. The interaction between the two mechanisms is generally believed mainly related to changes in nitric oxide / nitric oxide synthase, autonomic nervous system over activity, RhoA / Rho kinase and endothelin channel effects and pelvic atherosclerosis in four aspects. Phosphodiesterase type V inhibitors can improve bladder outlet obstruction by exerting a relaxing effect on the detrusor, urethra and prostatic smooth muscle. The use of either alone or in combination with a-blockers can effectively ameliorate the symptoms of lower urinary tract And quality of life score, combined effect is better.