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目的:探讨不同小茴香炮制品挥发油对急性血瘀模型大鼠血液流变性的影响。方法:大鼠连续给药7 d,第6天给药后1 h,除空白对照组外其余各组以皮下注射盐酸肾上腺素及冰水浴复制大鼠血瘀证模型。次晨药后1 h采血,测定血液流变学指标。结果:模型组血液流变学各指标明显升高;与模型组比较,小茴香生品及各炮制品挥发油能降低全血还原粘度、红细胞刚性指数和变形指数,且血浆比粘度、红细胞压积、红细胞沉降率和红细胞聚集指数也呈趋势下降。其中,蜜制小茴香挥发油对血液流变性的作用最为显著。结论:小茴香及其炮制品能明显改善大鼠血瘀模型的血液流变学异常,不同的炮制方法之间有较大差异,而蜜制小茴香改善效果最好。
Objective: To investigate the effects of volatile oil from different cumin processed products on the hemorheology of acute blood stasis model rats. Methods: The rats were continuously administered for 7 days and the rats on the 6th day were administered with epinephrine hydrochloride and ice-water bath to establish the model of blood stasis syndrome except the blank control group. Blood samples were collected 1 h after the morning treatment, and the hemorrheological parameters were measured. Results: Compared with the model group, the volatile oil of the cumin and the processed products reduced the whole blood reduced viscosity, erythrocyte rigidity index and deformation index, and the plasma specific viscosity, hematocrit , Erythrocyte sedimentation rate and erythrocyte aggregation index also showed a trend decline. Which, honey cumin volatile oil on the role of the most significant rheological. CONCLUSION: Cumin and its processed products can significantly improve the hemorheology abnormalities of blood stasis model in rats. There is great difference between different processing methods, while honey cumin has the best improvement effect.