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1974年,确认了肺部疾病与肺动脉高压间的关系。随后认识到肺动脉阻力血管对缺氧具有独特的收缩能力,从而推断缺氧引起的血管收缩,在气道阻塞患者肺动脉高压的产生中起决定性作用。虽然也认识到其他一些重要因素,如血管床被肺气肿破坏、肺泡内及胸腔内压力的增加等,但众多的临床医师仍持上述观点。然而以下两个长期氧气试验的新报告使这种概念需要重新予以考虑。
In 1974, the relationship between pulmonary disease and pulmonary hypertension was confirmed. It was subsequently recognized that pulmonary vascular resistance vessels have a unique ability to contract hypoxia, thus inferring hypoxia-induced vasoconstriction and playing a decisive role in the development of pulmonary hypertension in patients with airway obstruction. Although many other important factors are also recognized, such as the destruction of the vascular bed by emphysema, the increase of pressure in the alveoli and intrathoracic cavities, many clinicians still hold the above viewpoints. However, the new report of the following two long-term oxygen tests needs to be reconsidered.