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目的:观察美托洛尔对慢性心力衰竭患者的症状、心功能及心室重塑的影响。方法:慢性心力衰竭患者60例,左心室舒张末内径(LVEDD)≥58 mm,左心室射血分数(LVEF)≤0.45,NYHA心功能Ⅱ～Ⅳ级,经治疗随访8个月,包括治疗组33例[美托洛尔平均剂量(71.2±34.6)mg/d]和对照组27例。观察美托洛尔对心力衰竭患者的症状、心功能及心室重塑的影响。应用心脏彩色超声仪测定治疗前及治疗3个月、8个月左心室结构及心功能指标变化。结果:经过8个月治疗,治疗组对照组比较,LVEF上升(P<0.01),左心室收缩末容积下降(P<0.01),左心室舒张末容积下降(P<0.05)。结论:在强心、利尿、血管转换酶抑制剂基础上,应用美托洛尔能显著改善心力衰竭患者的症状、心功能及心室重塑。
Objective: To observe the effects of metoprolol on the symptoms, cardiac function and ventricular remodeling in patients with chronic heart failure. Methods: 60 patients with chronic heart failure, left ventricular end diastolic diameter (LVEDD) ≥ 58 mm, left ventricular ejection fraction ≤ 0.45, NYHA cardiac function Ⅱ ~ Ⅳ grade, after treatment for 8 months, including the treatment group 33 cases [mean dose of metoprolol (71.2 ± 34.6) mg / d] and 27 cases of control group. To observe the effects of metoprolol on the symptoms, cardiac function and ventricular remodeling in patients with heart failure. The change of ventricular structure and cardiac function before treatment, 3 months and 8 months of treatment were measured by colorimetric system. Results: After 8 months of treatment, LVEF increased (P <0.01), left ventricular end-systolic volume decreased (P <0.01) and left ventricular end-diastolic volume decreased in the control group (P <0.05). Conclusion: The application of metoprolol can significantly improve the symptoms, cardiac function and ventricular remodeling in patients with heart failure on the basis of cardiac, diuretic and angiotensin converting enzyme inhibitors.