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目的:探讨丙泊酚联合呼吸机辅助呼吸治疗难治性癫痫持续状态的临床疗效。方法:对12例使用苯二氮卓类和巴比妥酸盐类均不能终止发作难治性癫痫持续状态患者行呼吸机辅助机械通气,并给予丙泊酚抗癫痫治疗(首剂1～2mg/kg,持续2～3mg/(kg·h)微量泵泵入),待癫痫控制后逐渐减量直至停药。结果:12小时内有效率达到66.7%,未见丙泊酚输注综合征、代谢性酸中毒、低血压、恶心、呕吐等不良反应。结论:丙泊酚联合机械通气是治疗难治性癫痫持续状态的一种可选择的有效的治疗手段。
Objective: To investigate the clinical efficacy of propofol combined with ventilator-assisted ventilation in the treatment of refractory status epilepticus. Methods: Ventilatory-assisted mechanical ventilation was given to 12 patients with refractory status epilepticus who did not discontinue seizures using benzodiazepines and barbiturates, and propofol was given for antiepileptic therapy (first dose 1-2 mg / kg, continuous 2 ~ 3mg / (kg · h) pump pump), until the control of epilepsy tapering until withdrawal. Results: The effective rate reached 66.7% in 12 hours. There was no adverse reactions such as propofol infusion syndrome, metabolic acidosis, hypotension, nausea and vomiting. Conclusion: Propofol combined with mechanical ventilation is an effective and effective treatment for refractory status epilepticus.