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目的探讨脑梗死患者血尿酸水平检测的临床意义。方法血尿酸静脉采血,置于非抗凝试管中,3000r/min离心10min,将收集的上清液在-70℃的条件下保存。GMP-140、vWF、PAI-1采用ELISA双抗体夹心法,TXB2采用放射免疫法,尿酸采用尿酸酶法测定。结果脑梗死组患者的血管性假血友病因子值明显高于对照组,差异有统计学意义。脑梗死患者在血尿酸升高的同时,血小板α-颗粒膜蛋白和血栓素B2均明显升高,且两者有相关性。结论血尿酸水平升高与心脑血管内皮损伤密切相关,血尿酸通过其含量的上升使血小板过度激活,在脑梗死患者的血栓形成中发挥了核心作用。
Objective To investigate the clinical significance of serum uric acid level in patients with cerebral infarction. Methods Serum uric acid blood was collected and placed in non-anticoagulant tubes and centrifuged at 3000 r / min for 10 min. The collected supernatants were stored at -70 ° C. GMP-140, vWF, PAI-1 ELISA double antibody sandwich method, TXB2 using radioimmunoassay, uric acid determination by uricase. Results The values of von Willebrand factor in patients with cerebral infarction were significantly higher than those in control group, the difference was statistically significant. Cerebral infarction in patients with elevated serum uric acid, platelet α-granule membrane protein and thromboxane B2 were significantly increased, and the two are related. Conclusions The elevated serum uric acid level is closely related to cardiovascular and endothelial injury. Serum and uric acid may activate platelets by increasing the content of uric acid, which plays a central role in the thrombosis of patients with cerebral infarction.