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目的 了解中国北方老年人群血浆维生素D水平的季节变化。方法 对 85名健康老年人 ,男 44名 ,(66 9± 3 8)岁 ,女 41名 ,(63 8± 3 8)岁 ,用放射免疫分析法测定春秋两季血浆 2 5(OH)D和继发性甲状旁腺素 (PTH)含量。结果 无论男女秋季血浆 2 5(OH)D水平明显高于春季 (男性高52 7% ,女性高 89 4% ,P <0 0 5) ,同一季节内男女间差异无显著性。维生素D缺乏率 :女性 :春季为63 4% ,秋季为 7 3 %。男性 :春季为 65 9% ,秋季没有缺乏者。春季维生素D缺乏率显著高于秋季(P <0 0 5)。男女秋季血浆PTH浓度明显低于春季 (男性低 2 9 2 % ,女性低 2 0 6 % ,P <0 0 5)。老年女性春季血浆 2 5(OH)D浓度和血浆PTH浓度之间呈负相关 (r = 0 42 6 ,P <0 0 0 1 )。结论 该人群血浆 2 5(OH)D和PTH有明显的季节变化 ,春季血浆 2 5(OH)D水平很低
Objective To understand the seasonal changes of plasma vitamin D levels in the elderly in northern China. Methods Totally 85 healthy elderly, 44 males, 669 ± 38 females, 41 females, and 63 8 ± 38 females were enrolled in this study. Plasma 2 5 (OH) D concentrations in spring and autumn were measured by radioimmunoassay And secondary parathyroid hormone (PTH) levels. Results There was no significant difference between men and women in the same season, no matter whether the level of plasma 2 5 (OH) D was lower in men and women in autumn than in spring (52 7% in males and 89 4% in females, P <0 05). Vitamin D deficiency rate: Women: 63 4% in spring and 73% in autumn. Men: 65.9% in spring, no lack of fall. Vitamin D deficiency in spring was significantly higher than that in autumn (P <0 05). Plasma PTH concentrations were significantly lower in both men and women in autumn than in spring (29.2% for males and 2.6% for females, P <0 05). There was a negative correlation between plasma 25 (OH) D concentration and plasma PTH concentration in elderly women (r = 0 42 6, P 0 01). Conclusions The plasma 25 (OH) D and PTH have obvious seasonal changes in this population. The plasma 25 (OH) D level in spring is very low