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目的提高对腮腺低度恶性筛状囊腺癌的认识。方法通过对1例腮腺低度恶性筛状囊腺癌的临床资料和免疫组化结果进行分析,并复习国内外相关文献。结果腮腺低度恶性筛状囊腺癌是由单个或多个囊及邻近的导管内增生构成,导管内增生的导管上皮呈筛状、微乳头状和实性。免疫组化染色,导管内筛状增生细胞S-100弥漫阳性,Ki-67呈阳性,导管肌上皮细胞P63阳性。此例患者经过根治性手术后随访1a无复发。结论腮腺低度恶性筛状囊腺癌在临床上是一种罕见的涎腺肿瘤,其确诊主要依靠病理学免疫组化检查,治疗以根治性手术为主。
Objective To improve the awareness of low grade parotid glandular cystadenocarcinoma. Methods The clinical data and immunohistochemistry results of 1 case of low grade parotid glandular cystadenocarcinoma were analyzed and the related literatures at home and abroad were reviewed. Results Low parotid glandular cystadenocarcinoma is composed of single or multiple cysts and adjacent intraductal hyperplasia, hyperplasia of ductal epithelium was sieved, micro-papillary and solid. Immunohistochemical staining revealed diffusely positive S-100 proliferative cells in the duct, Ki-67 positive and P63 positive in ductal myoepithelial cells. This patient had no recurrence after follow-up la after radical surgery. Conclusions Low parotid glandular cystadenocarcinoma is clinically a rare salivary gland tumor. The diagnosis of salivary gland tumor is mainly based on pathological immunohistochemistry. The treatment is mainly based on radical surgery.