目的了解上海市杨浦区无偿献血者HIV感染现状,更好的制定防控策略,进一步保障临床用血安全。方法对2006-2014年上海市杨浦区195 355份无偿献血者血液筛查标本进行HIV项目常规检测,对其中HIV抗体确认阳性的34名无偿献血者的献血资料进行调查分析。结果 2006-2014年上海市杨浦区无偿献血者HIV抗体确认阳性率从2010年开始呈现增长趋势。感染者以男性为主,比例为94.1%,年龄分布18-30岁的比例为64.71%,31-40岁为26.47%,41-55岁为8.82%,感染人群以青壮年为主。结论上海市杨浦区无偿献血人群中HIV感染率呈逐年增长态势,应加强宣传并制定一系列防控措施和人群筛选策略,以确保血液安全。 Objective To understand the status of HIV infection in unpaid blood donors in Yangpu District of Shanghai and to better develop prevention and control strategies to further ensure the safety of clinical blood use. Methods A total of 195 355 blood donors in Yangpu district of Shanghai from 2006 to 2014 were routinely tested for HIV. Blood donation data of 34 unpaid blood donors with HIV antibody positive were investigated. Results The positive rate of confirmed HIV antibody in blood donors in Yangpu District of Shanghai from 2006 to 2014 showed an increasing trend from 2010 onwards. Infected mainly men, the proportion was 94.1%, the age distribution of 18-30 years old was 64.71%, 31-40 years old was 26.47%, 41-55 years old was 8.82%, young people infected mainly. Conclusion The HIV infection rate in unpaid blood donation population of Yangpu District in Shanghai is increasing year by year. A series of prevention and control measures and population screening strategies should be strengthened to ensure blood safety.