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结肠癌发病率在亚洲国家明显上升,其发病率日趋接近欧美发达国家,也是我国十分常见的恶性肿瘤,占全部胃肠道癌的第1～2位,成为威胁城市居民健康的主要疾病之一。结肠癌与其他肿瘤的发生一样也是一个多步骤的过程,一般认为是细胞内的重要调控基因损伤,伴随生化信号传递系统功能失调所致,在肿瘤基因中,ras基因的突变和结肠癌的关系非常密切,ras家族中K-ras基因又因为其高突变率而成为了ras基因研究的一个热点。作者就K-ras基因及该基因在结肠癌中的研究及应用情况综述如下。
The incidence of colon cancer in Asian countries increased significantly, the incidence of increasingly close to Europe and the United States developed countries, is also a very common malignant tumor in our country, accounting for all gastrointestinal cancer 1 to 2, a threat to urban health, one of the major diseases . Colon cancer, like other tumors, is also a multi-step process, which is generally considered to be an important regulated gene injury in cells. With the dysfunction of biochemical signal transduction system, the relationship between the ras gene mutation and colon cancer in the tumor gene Very closely, ras family K-ras gene and because of its high mutation rate has become a ras gene research hotspot. The author of K-ras gene and the gene in colon cancer research and application are summarized below.