目的 :观察原发性翼状胬肉单纯切除术中使用丝裂霉素C对预防复发的效果及安全性。方法 :对 1997年 10月至 1999年 3月门诊原发性翼状胬肉患者施行单纯切除术 ,并在翼状胬肉切除后立即用浸有 0 0 1%丝裂霉素C的棉片覆盖 5min。对照组仅施行单纯切除术 ,不使用丝裂霉素C。随访观察 6～ 12个月。结果 :72只单纯切除术联合应用丝裂霉素C的患眼有 9只眼复发 ,复发率为 12 5 0 % ,未发现任何严重并发症。对照组 198只眼有 76只眼复发 ,复发率为 38 38%。两者差异有显著性。结论 :在术中联合应用丝裂霉素C能够减少原发性翼状胬肉单纯切除术后的复发 ,并且安全。 Objective: To observe the efficacy and safety of mitomycin C in preventing recurrence in primary pterygium resection. METHODS: Patients undergoing primary pterygium from October 1997 to March 1999 underwent simple resection and were covered with a piece of cotton coated with 0 0 1% mitomycin C immediately after excision of the pterygium for 5 min . The control group only performed a simple resection, do not use mitomycin C. Follow-up observation of 6 to 12 months. Results: Seventy-two resections combined with mitomycin C had recurrence in 9 eyes with a recurrence rate of 125.0%. No serious complications were found. In the control group, 76 of the 198 eyes had a recurrence with a relapse rate of 38.38%. The difference was significant. Conclusion: Mitomycin C combined with intraoperative use can reduce the recurrence of primary pterygium resection and is safe.