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本文对哮喘、喘支患儿各27例及42例正常儿童用McAb进行外周血T_3~+(成熟T细胞)、T_4~+(辅助/诱导T细胞)、T_8~+(抑制/杀伤T细胞)及T_4~+/T_8~+比值的检测。结果:内、外源性哮喘患儿及有湿疹史和家族过敏史的喘支患儿其T_3~+、T_(?)~+细胞低于正常儿童,T_4~+/T_(?)~+比值高于正常儿童。推测细胞免疫功能低下和抑制性T细胞缺陷是发生喘息的机制。经对哮喘和喘支的临床特点进行分析,发现他们存在共同的遗传问题,哮喘中85%于3岁内首次发病。本文认为3岁以内的婴幼儿也可患哮喘。特別应高度重视有湿疹史和家族过敏史的喘支患儿,若其血清总IgE升高,可认为该部分喘支患儿实际上是嬰幼儿哮喘。
In this paper, 27 cases of asthmatic children with bronchiectasis and 42 cases of normal children were treated with McAb for T_3 ~ + (T cells), T_4 ~ + (T helper / T cells), T_8 ~ + / T cells ) And T_4 ~ + / T_8 ~ + ratio of the test. Results: The levels of T_3 ~ +, T_ (~) ~ + cells in children with extrinsic asthma and those with history of eczema and familial allergies were significantly lower than those in normal children. T_4 ~ + / T_ (~) ~ Ratio higher than normal children. It is hypothesized that cellular immune dysfunction and suppressor T cell defects are mechanisms for wheezing. The clinical features of asthma and asthma were analyzed and found that they shared a common genetic problem, 85% of asthma in the first 3 years of age. This article considers that infants and children within 3 years of age may also suffer from asthma. In particular, should pay great attention to history of eczema and family history of asthma in children with asthma, if the serum total IgE increased, that part of the asthmatic children is actually asthma in infants and young children.