目的探讨硝苯地平对减少静脉滴注红霉素的胃肠道不良反应的效果。方法观察组 (5 6例 )在静脉滴注红霉素前 30～ 6 0分钟口服硝苯地平 ,并与对照组 (4 8例 )静脉滴注红霉素前静脉滴注维生素B6进行对照。结果观察组患儿胃肠道反应与对照组相比有明显差异 (P <0 .0 1)。结论口服硝苯地平预防静脉滴注红霉素所致胃肠道不良反应疗效确切。 Objective To investigate the effect of nifedipine on reducing gastrointestinal adverse reactions caused by intravenous infusion of erythromycin. Methods The observation group (n = 56) received oral nifedipine 30 to 60 minutes before the intravenous infusion of erythromycin, and the control group (48 patients) received intravenous infusion of erythromycin before intravenous injection of vitamin B6. Results The gastrointestinal reaction in observation group was significantly different from that in control group (P <0.01). Conclusions Oral nifedipine is effective in preventing gastrointestinal adverse reactions caused by intravenous infusion of erythromycin.