论文部分内容阅读
在青黴素用到臨床上的最初幾年,各國廠商的製品都是淺黄色以至棕色的無定形粉末。這種青黴素製品的質量不够純净,使用時在注射部位感覺疼痛,其最大的缺點是保存性不佳,需要冷藏。關於青黴素的提純和精製,曾經很多人用各種力法做了很多研究工作。在1945年以後,青黴素製品幾乎全部是耐熱的白色晶體。在1943年7月間,Wintersteiner氏等首次獲得苄青黴素鈉鹽晶體,随後Abraham諸氏又作出晶形的戊烯[2]青黴素。這些結果都是研究青黴素的化
In the first few years of the clinical application of penicillin, the products of various manufacturers were amorphous yellow powders and brown powders. The quality of this penicillin product is not pure enough, and it feels painful at the injection site when used. Its greatest drawback is poor preservation and requires refrigeration. Regarding the purification and refining of penicillin, many people have done a lot of research work with various methods. After 1945, penicillin products were almost all heat-resistant white crystals. In July 1943, Wintersteiner et al. obtained crystals of phenicillin sodium salt for the first time, followed by Abraham Zhun made the crystalline pentene[2] penicillin. These results are all related to the study of penicillin