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目的 :探讨乳腺癌 ER、PR与癌组织的组织学类型、核分极、纤维间质增生及患者年龄等因素的关系。方法 :用免疫组织化学方法 (S- P)检测 ER、PR在 38例乳腺癌中的表达 ,并分析与癌组织诸因素的关系。结果 :38例乳腺癌共有 ER阳性 19例、PR阳性 18例 ,ER、PR均阳性 2 0例 ,C- er B- 2阳性 14例。结论 :ER、PR在老年患者、分化好的细胞核、癌组织有明显的纤维间质增生 ,显示较高的阳性率 ,而在髓样癌、粉刺性导管癌中往往显示很低的阳性率 ,ER、PR的阳性率与 C- er B- 2的阳性率呈反变关系 ,C- er B- 2的阳性率与癌组织的组织学分级呈反变关系
Objective: To investigate the relationship between breast cancer ER, PR and histological types, nuclear polarization, interstitial fibrosis and patient’s age. Methods: The expressions of ER and PR in 38 cases of breast cancer were detected by immunohistochemical method (S-P). The relationship between the expression of ER and PR and other factors in cancer tissues was analyzed. Results: There were 19 ER positive cases and 18 PR positive cases in 38 cases of breast cancer. There were 20 cases positive for ER and PR and 14 cases positive for C er-2. Conclusion: ER, PR in elderly patients with well-differentiated nuclei and cancerous tissue have obvious fibrovascular interstitial hyperplasia, showing a high positive rate, while in medullary carcinoma and acne ductus carcinoma often show a low positive rate, The positive rates of ER and PR were negatively correlated with the positive rates of C er-2, and the positive rates of C-er B-2 were inversely correlated with the histological grade of cancerous tissues