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目的探讨血管紧张素转换酶（ＡＣＥ）基因多态性与２型糖尿病脑梗塞间的关系。方法应用多聚酶链反应（ＰＣＲ）技术，对１０９名２型糖尿病患者及５２名正常对照者的ＡＣＥ基因插入／缺失（Ｉ／Ｄ）型多态性进行检测，并用Ｌｏｇｉｓｔｉｃ多元逐步回归，筛选出２型糖尿病患者脑梗塞的高危因素。结果（１）糖尿病总组ＡＣＥ基因型频率和等位基因频率与正常对照组无显著性差异（Ｐ＞０．０５）。（２）糖尿病脑梗塞组ＡＣＥ基因ＤＤ型和Ｄ等位基因频率显著高于非脑梗塞组（Ｐ＜０．０１）及正常对照组（Ｐ＜０．０５）。（３）多元逐步回归分析显示：ＡＣＥ基因ＤＤ型、Ｄ等位基因、脂蛋白（ａ）及年龄是糖尿病脑梗塞的独立危险因素，而ＡＣＥ基因ＩＩ型和Ｉ等位基因则为２型糖尿病脑梗塞的保护因子。结论ＡＣＥ基因Ｉ／Ｄ多态性与２型糖尿病脑梗塞的发病密切相关。ＡＣＥ基因
Objective To investigate the relationship between angiotensin converting enzyme (ACE) gene polymorphism and type 2 diabetes mellitus (CI). Methods ACE gene insertion / deletion (I / D) polymorphism was detected in 109 patients with type 2 diabetes mellitus and 52 normal controls by polymerase chain reaction (PCR). Logistic regression was used to identify 2 Risk factors for cerebral infarction in type. Results (1) There was no significant difference in ACE genotype frequency and allele frequency between the two groups (P> 0.05). (2) The frequency of DD and D allele of ACE gene in diabetic cerebral infarction group was significantly higher than that in non-cerebral infarction group (P <0.01) and normal control group (P <0.05). (3) Multivariate stepwise regression analysis showed that DD genotype, D allele, lipoprotein (a) and age were the independent risk factors for diabetic cerebral infarction, while the ACE gene type II and I alleles were type 2 diabetes mellitus Protection factor of cerebral infarction. Conclusion ACE gene I / D polymorphism is closely related to the incidence of type 2 diabetes mellitus. ACE gene