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目的:评估左室舒张末期压力(LVEDP)与冠心病(CHD)及冠状动脉(冠脉)病变严重程度之间的关系。方法:连续入选同时行冠脉造影(CAG)及左心导管检查的患者912例,根据CAG结果分为CHD组(599例)和非CHD组(313例)。依据Gensini评分及病变血管数目评估冠脉病变严重程度。分析LVEDP与CHD及冠脉病变严重程度之间的关系。结果:与非CHD组患者相比较,CHD组患者LVEDP明显升高[(10.9±5.46)mmHg︰(9.58±5.78)mmHg,P<0.001],且LVEDP与CHD独立相关(OR=1.11,95%CI:1.02~1.29,P=0.02)。随着病变血管数目增加,LVEDP逐渐增加(P<0.001)。多因素线性相关分析显示,LVEDP与Gensini评分明显相关(β=0.034,P=0.001)。在非CHD组患者中,LVEDP仅与年龄相关(r=0.123,P=0.030)。结论:LVEDP的增加与CHD及严重程度明显相关;在非CHD患者中,LVEDP的增加仅与年龄相关。LVEDP的测量可对CHD及非CHD患者提供额外的临床价值。
PURPOSE: To evaluate the relationship between left ventricular end diastolic pressure (LVEDP) and the severity of coronary artery disease (CHD) and coronary artery disease (coronary artery disease). Methods: A total of 912 consecutive patients undergoing coronary angiography (CAG) and left heart catheterization were enrolled. The patients were divided into CHD group (599 cases) and non-CHD group (313 cases) according to CAG results. The severity of coronary lesions was assessed by Gensini score and the number of diseased vessels. Analysis of the relationship between LVEDP and CHD and the severity of coronary lesions. Results: LVEDP was significantly higher in patients with CHD compared with patients without CHD [(10.9 ± 5.46) mmHg: (9.58 ± 5.78) mmHg, P <0.001], and LVEDP was independently associated with CHD (OR = 1.11, 95% CI: 1.02-1.29, P = 0.02). LVEDP gradually increased as the number of vascular lesions increased (P <0.001). Multivariate linear correlation analysis showed that LVEDP was significantly associated with Gensini score (β = 0.034, P = 0.001). Among non-CHD patients, LVEDP was only age-related (r = 0.123, P = 0.030). CONCLUSIONS: The increase in LVEDP was significantly associated with CHD and severity; in non-CHD patients, the increase in LVEDP was only age-related. LVEDP measurement can provide additional clinical value to CHD and non-CHD patients.