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目的探讨分析替格瑞洛在老年急性ST段抬高型心肌梗死(STEMI)患者急诊经皮冠状动脉介入治疗(PCI)中的临床疗效和安全性。方法 66例老年STEMI患者,依据来院时间分为研究组与参照组,各33例。研究组患者予以氯吡格雷治疗,参照组予以替格瑞洛治疗,对比两组临床疗效。结果研究组不良事件发生率为6.1%,明显低于参照组的24.2%,差异有统计学意义(P<0.05);研究组并发症发生率为6.1%,明显低于参照组的27.3%,差异有统计学意义(P<0.05);研究组患者TIMI分级情况明显好于参照组,差异有统计学意义(P<0.05);研究组患者心功能指标改善情况好于参照组,差异有统计学意义(P<0.05)。结论在老年STEMI患者急诊PCI中应用替格瑞洛治疗,其效果显著,且安全性相对较高,可以进一步的应用和实践。
Objective To investigate the clinical efficacy and safety of ticagrelor in the emergency percutaneous coronary intervention (PCI) in elderly patients with acute ST-segment elevation myocardial infarction (STEMI). Methods Sixty-six elderly STEMI patients were divided into study group and reference group according to the time of admission. Patients in the study group were treated with clopidogrel, while those in the reference group were treated with ticagrelor. The clinical efficacy was compared between the two groups. Results The incidence of adverse events in the study group was 6.1%, which was significantly lower than that in the reference group (24.2%, P <0.05). The incidence of complications in the study group was 6.1%, significantly lower than that in the reference group (27.3% The difference was statistically significant (P <0.05); TIMI grading in study group was significantly better than the reference group, the difference was statistically significant (P <0.05); study group patients with cardiac function improved better than the reference group, the difference was statistically significant Significance (P <0.05). Conclusion The application of ticagrelor in the treatment of elderly patients with STEMI in emergency PCI has significant effect and relatively high safety, which can be further applied and practiced.