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通过对１１例急性白血病患者单独化疗与化疗后加用粒细胞集落刺激因子（Ｇ－ＣＳＦ）的对比，动态观察了Ｇ－ＣＳＦ对外周血造血干细胞（ＰＢＳＣ）的动员作用。发现化疗后加用Ｇ－ＣＳＦ比单用化疗的粒－巨噬细胞集落形成单位（ＣＦＵ－ＧＭ）增加５．１倍，红系爆式集落形成单位（ＢＦＵ－Ｅ）增加４．５倍。Ｇ－ＣＳＦ还可使ＣＦＵ－ＧＭ＞１００／ｍｌ和ＢＦＵ－Ｅ＞２００／ｍｌ的持续时间延长；化疗后ＣＦＵ－ＧＭ的最高值提早出现，而不影响ＢＦＵ－Ｅ／ＣＦＵ－ＧＭ比值。结果表明，化疗后加用Ｇ－ＣＳＦ可明显提高ＰＢＳＣ的收集效率，Ｇ－ＣＳＦ是一种有效的ＰＢＳＣ动员剂。
The mobilization of G-CSF peripheral blood hematopoietic stem cells (PBSC) was dynamically observed in 11 patients with acute leukemia who were treated with chemotherapy and chemotherapy plus granulocyte colony-stimulating factor (G-CSF). It was found that the addition of G-CSF after chemotherapy was a 5.1-fold increase in granulocyte-macrophage colony-forming units (CFU-GM) compared to chemotherapy alone, and a 4.5-fold increase in BFU-E. G-CSF also prolonged the duration of CFU-GM>100/ml and BFU-E>200/ml; the highest value of CFU-GM appeared earlier after chemotherapy without affecting the BFU-E/CFU-GM ratio. The results showed that the addition of G-CSF after chemotherapy can significantly increase the collection efficiency of PBSC. G-CSF is an effective PBSC mobilizer.